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NFLNov 15, 2026AT&T StadiumFox

Pregame

49ers vs Cowboys Prediction, Odds & Picks

Week 10 features the 49ers at the Cowboys with the 49ers installed as 3.5-point road favorites.

By the OddsListing desk · Published

SF

7-1

4:25 PM ET

DAL

4-5

Scores from the ESPN board

At a glance

Pregame line

Spread
SF −3.5 (−118)DAL +3.5 (−102)
Total
O 55.5 (−118)U 55.5 (−102)
Moneyline
SF −205 (64%)DAL +170 (36%)

Our lean

Cowboys +3.5 (-105)Why

DraftKings via ESPN · line at publication · Nov 11, 3:40 AM ET

DraftKings via ESPN · Pregame line · as of 1:02 PM ET. % = no-vig win share (hold removed; arithmetic, not a forecast).

The 49ers visit the Cowboys in Week 10 of the regular season at AT&T Stadium on Sunday afternoon.

Our lean

Spread

Cowboys +3.5 (-105)

DraftKings via ESPN · line at publication, Nov 11, 3:40 AM ET

Break-even at -105: 51.2% · Market, vig removed: Cowboys +3.5 48.9% · Cowboys to win 35.5%

The Cowboys receive 3.5 points after the market moved in their direction from the opening line. Their offense has produced 27.3 points per game while the 49ers have allowed 19.5, a gap the current price appears to acknowledge.

The case against

The 49ers hold a 7-1 record and have scored 29.4 points per game on average, numbers that suggest they could cover the spread despite the line movement toward the Cowboys.

What our lean is, and isn’t

49ers outlook

The 49ers enter with a 7-1 record and have scored 29.4 points per game while allowing 19.5. Their recent results show a win over the Raiders followed by a loss at the Falcons.

Brock Purdy leads the passing attack while Christian McCaffrey tops the rushing totals. Gracen Halton and C.J. West remain on injured reserve, and several wide receivers carry questionable tags.

Six days separate their most recent outing from this contest, a schedule spot that follows a win and a road loss.

Cowboys outlook

The Cowboys sit at 4-5 and have scored 27.3 points per game while allowing 26.2. Their last five games include a win at the Colts followed by an overtime loss to the Cardinals.

Dak Prescott leads the passing attack and Javonte Williams leads in rushing. Multiple defensive and offensive players, including DeMarvion Overshown and George Pickens, are listed as questionable.

Six days separate their most recent outing from this contest, a schedule spot that follows a road win.

Key matchup

The 49ers rushing attack that produces 135.3 yards per game faces a Cowboys defense that has allowed 147.4 rushing yards per game, an area that could shape the outcome given both clubs' recent scoring outputs.

The market

DraftKings lists the 49ers at -3.5 and the Cowboys at +3.5. The total sits at 55.5. Since the opening line the spread moved from Cowboys -1.5 to 49ers -3.5 while the total remained at 55.5.

Written with AI assistance from ESPN data and checked by a separate automated fact-check against that data. Lines as of Nov 11, 3:40 AM ET from DraftKings; they move — confirm the price before you bet. 21+. Gambling problem? Call 1-800-GAMBLER. How we write previews

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Market read

DraftKings via ESPN

Pregame line · as of 1:02 PM ET

MarketNowOpenedChangeNo-vig %HoldAs of
SF spread−3.5 −118−4.5 −102+1 pts51.7%4.6%1:02 PM ET
DAL spread+3.5 −102+4.5 −118−1 pts48.3%
Over55.5 −11855.5 −115−3¢51.7%4.6%1:02 PM ET
Under55.5 −10255.5 −105+3¢48.3%
SF ML−205−218+13¢64.5%4.3%1:02 PM ET
DAL ML+170+180−10¢35.5%

Now: numbers as published on ESPN at the time shown, a snapshot, not a live price. Opened: the first DraftKings line we recorded, Nov 10, 10:00 AM ET. Change: points for spreads and totals, cents for prices (−110 to −120 is −10¢).

No-vig % removes the book's margin from each market's prices, and hold is that margin: arithmetic on these numbers, not a forecast or a betting-split feed.

Where to bet this game

Check the price at a book we review

Prices vary by book. We only show lines we can source with a timestamp. 21+.

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Injury report

San Francisco 49ers

  • Trent Williams · OT — Questionable (Shoulder)
  • Dre Greenlaw · LB — Questionable (Knee)
  • Mike Evans · WR — Questionable (Achilles, Tendinitis)
  • Deebo Samuel Sr. · WR — Questionable (Hamstring)
  • C.J. West · DT — Injured Reserve (Knee)

Dallas Cowboys

  • George Pickens · WR — Questionable (Hamstring)
  • Jonathan Mingo · WR — Questionable (Ankle)
  • KaVontae Turpin · WR — Questionable (Ribs)
  • Juanyeh Thomas · S — Questionable (Ribs)
  • Alijah Clark · S — Questionable (Illness)

Status from ESPN as of Nov 13. Lineups are not confirmed until teams announce them.

Recent form

San Francisco 49ers

  • W 38-17 vs LV · Nov 8
  • L 29-20 @ ATL · Oct 25
  • W 23-17 vs WSH · Oct 19
  • W 32-29 @ SEA · Oct 11
  • W 24-14 vs DEN · Oct 4

Dallas Cowboys

  • W 27-23 @ IND · Nov 8
  • L 33-30 OT vs ARI · Nov 1
  • W 38-21 @ PHI · Oct 26
  • L 23-13 @ GB · Oct 18
  • L 24-16 vs TB · Oct 8

Season leaders

San Francisco 49ers

  • Passing Yards: Brock Purdy — 163/236, 1,980 YDS, 17 TD, 5 INT
  • Rushing Yards: Christian McCaffrey — 102 CAR, 457 YDS, 9 TD
  • Receiving Yards: George Kittle — 38 REC, 483 YDS, 5 TD

Dallas Cowboys

  • Passing Yards: Dak Prescott — 218/336, 2,381 YDS, 16 TD, 5 INT
  • Rushing Yards: Javonte Williams — 154 CAR, 629 YDS, 9 TD
  • Receiving Yards: CeeDee Lamb — 70 REC, 904 YDS, 7 TD

From the NFL desk

More news

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Keenan Allen Energized by Trade to 49ers

NFL2d ago

Williams Leads Cowboys Defense a Year After Trade

NFL3d ago

49ers Land Keenan Allen in Deadline Deal

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